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    Vesicular Structures Self-Assembled from Oligonucleotide-Polymer Hybrids: Mechanical Prevention of Bacterial Colonization Upon their Surface Tethering Through Hybridization

    Year: 2012

    Journal: Advanced Functional Materials Volume 22, Issue 23, pages 4891–4898, December 5, 2012, 20130119

    Authors: Nicolas Cottenye 1 2, Karine Anselme 1, Lydie Ploux 1, Corinne Vebert-Nardin 2 † *

    Last authors: Corinne Vebert-Nardin

    Organizations: 1
Institut de Science des Matériaux de Mulhouse, (IS2M, CNRS LRC 7228), 15 rue Jean Starcky, BP 2488, 68057 Mulhouse Cedex, France 2
Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland †
Department of Inorganic and Analytical Chemistry University of Geneva Quai Ernest-Ansermet, 30 CH-1211 Geneva 4, Switzerland


    Country: Switzerland, France

    In order to design soft coatings, surface tethering of vesicular structures self-assembled from oligonucleotide-polymer hybrids is achieved through hybridization. Watson-Crick base-pairing occurs between the nucleotide sequences involved in the self-assembly and their surface-tethered complementary sequences. Combining the quartz crystal microbalance and in situ observations using confocal laser scanning microscopy, it is evidenced that the vesicles retain their morphology even under flow stress. Surprisingly, these soft surfaces prevent bacterial colonization.