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    Viscoelastic properties of fibrinogen adsorbed onto poly(ethylene terephthalate) surfaces by QCM-D

    Year: 2013

    Journal: Carbohydrate Polymers Volume 93, Issue 1, 1 March 2013, Pages 246–255, 20130402

    Authors: Aleš Doliška 1, Volker Ribitsch 2, Karin Stana Kleinschek 2, Simona Strnad 1

    Last authors: Simona Strnad

    Organizations: 1 Laboratory for Characterization and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia 2 Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstraße 28/III, AT-8010 Graz, Austria

    Country: Slovenia, Austria

    In presented study a new approach using QCM-D for biocompatibility determination was introduced. The adsorption of fibrinogen on PET and modified PET surfaces was monitored in situ using QCM-D. Protein layer thicknesses were estimated on the basis of a Voight based viscoelastic model. The hydrophilicities and morphologies of the surfaces were investigated using a goniometer and AFM. The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces. QCM-D equipped with QTools modelling software is well-applicable to the characterisation of surface properties and can be optimised for biocompatibility determination.