Voltammetric study and surface pressure isotherms describing Flunitrazepam incorporation into a distearoylphosphatidic acid film adsorbed at air/water and water/1,2-dichloroethane interfaces

The effect of Flunitrazepam (FNTZ) on molecular packing of distearoylphosphatidic acid (DSPA) adsorbed at the air/water and the water/1, 2–dichloroethane interface was investigated using cyclic voltammetry (CV) and surface pressure–molecular area isotherm. FNTZ incorporation into the DSPA monolayer changes the state of the film. The results indicate that a structuring effect dependent on the pH and the cation present in the base aqueous electrolyte takes place, which leads to a decrease in the permeability of the film.