When cyclodextrins meet click chemistry

Cyclodextrins are important building blocks in organic chemistry. This review deals with the role of click chemistry in this family of cyclic oligosaccharides, focusing on the different areas of chemistry, including chromatography, biological applications, the elaboration of superstructures, and metal detection, that benefit from this reaction. In this paper, attention is given to organic modifications by using functionalizations such as azidation and propargylation and to click chemistry grafting onto the two faces of cyclodextrins. Research papers where cyclodextrins are not directly involved in a click chemistry reaction are not considered. A summary of chemical advances in the fields of chromatography, biological applications, the elaboration of superstructures, and metal detection is given when cyclodextrins meet the copper-catalyzed azide-alkyne cycloaddition reaction.