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    A magnetic micro-environment in scaffolds for stimulating bone regeneration

    Year: 2020

    Journal: Mater. Des., Volume 185, JAN 5

    Authors: Shuai, Cijun; Yang, Wenjing; He, Chongxian; Peng, Shuping; Gao, Chengde; Yang, Youwen; Qi, Fangwei; Feng, Pei

    Organizations: Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51935014, 51905553, 81871494, 81871498, 51705540]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ50774, 2018JJ3671, 2019JJ50588]; JiangXi Provincial Natural Science Foundation of China [20192ACB20005]; Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2018); Project of Hunan Provincial Science and Technology Plan [2017RS3008]; National Postdoctoral Program for Innovative Talents [BX201700291]; Shenzhen Science and Technology Plan Project [JCYJ20170817112445033]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M632983]; Project of State Key Laboratory of High Performance Complex Manufacturing, Central South University; Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University; Fundamental Research Funds for the Central Universities of Central South University [CX20190061]

    Keywords: Magnetic scaffolds; Fe3O4 nanoparticles; Magnetic stimulation; Bone regeneration

    In present study, a strategy is presented to construct a magnetic micro-environment in poly-(L)-lactide/polyglycolic acid (PLLA/PGA) scaffolds fabricated via selective laser sintering by incorporating Fe3O4 magnetic nanoparticles (MNPs), aiming to enhance cell viability and promote bone regeneration. In the micro-environment, each nanoparticle provides a nanoscale magnetic field to activate cellular responses. The results in vitro demonstrated that the magnetic scaffolds not only stimulated cell adhesion and viability, but also enhanced proliferation rate and alkaline phosphatase activity. Meanwhile, the compressive strength and modulus were increased by 81.9% and 71.6%, respectively, which were determined by the rigid enhancement effect of MNPs. Moreover, the magnetic scaffolds were implanted into rabbit radius bone defect in vivo, and the results indicated that the magnetic scaffolds significantly induced substantial blood vessel tissue, fibrous tissue and new bone tissue formation at 2 months post-implantation, revealing the excellent bone regeneration capability. These positive results indicate that the construction of magnetic micro-environment in scaffolds is a working countermeasure to promote bone regeneration. (C) 2019 The Authors. Published by Elsevier Ltd.
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