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    A nanoscale redox-active composite as a low-fouling interface for capacitive assaying

    Year: 2019

    Journal: Sens. Actuator B-Chem., Volume 291, JUL 15, page 493–501

    Authors: Bedatty Fernandes, Flavio C.; Andrade, Juliana R.; Bueno, Paulo R.

    Organizations: Sao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Brazilian National Council for Scientific and Technological Development (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ); Royal SocietyRoyal Society of LondonEuropean Commission; FAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

    Keywords: Low-fouling; Zwitterionic compound; Immittance function electro-analysis; Nanoscale composite; Electrochemical impedance spectroscopy

    An electro-active nanoscale composite was engineered to serve as an alternative to monolayers in a capacitive biosensing platform. An electrochemical impedance-derived spectroscopic method was applied to analyse the response of this nanoscale (c.a. 9 nm thickness) composite to detect C-reactive protein. The composite was successfully assembled over a conductive electrode and built up by conjugating graphene oxide sheets into a self-assembled 11-ferrocenyl-undecanethiol structure, forming a molecular composite concomitantly coated with zwitterionic methacrylate-based monomers that served as the non-fouling component of the composite. Finally, the functionalization of a composite with receptors allowed the successful testing of its electro-analytical ability to detect C-reactive protein in both phosphate-buffered saline and neat human serum samples.
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