Contact
    Start Publications A Polyphenol-Network-Mediated Coating Modulates Inflammation ...
    ←  Publication Finder
    Attension

    A Polyphenol-Network-Mediated Coating Modulates Inflammation and Vascular Healing on Vascular Stents

    Year: 2022

    Journal: ACS Nano, Volume 16, APR 26, page 6585–6597

    Authors: Zhang, Bo; Qin, Yumei; Yang, Li; Wu, Ye; Chen, Nuoya; Li, Mingyu; Li, Yanyan; Wan, Huining; Fu, Daihua; Luo, Rifang; Yuan, Lu; Wang, Yunbing

    Organizations: National Natural Science Foundation of China [82102218]; China Postdoctoral Science Foundation [2021M692317]; Sichuan Science and Technology Program [2021YFH0011]; 111 Project (Program of Introducing Talents of Discipline to Universities) [B16033]

    Keywords: antirestenosis; antithrombogenicity; cardiovascular stent; endothelialization; inflammatory regulation; polyphenol-Cu network

    Localized drug delivery from drug-eluting stents (DESs) to target sites provides therapeutic efficacy with minimal systemic toxicity. However, DESs failure may cause thrombosis, delay arterial healing, and impede re-endothelialization. Bivalirudin (BVLD) and nitric oxide (NO) promote arterial healing. Nevertheless, it is difficult to combine hydrophilic signal molecules with hydrophobic antiproliferative drugs while maintaining their bioactivity. Here, we fabricated a micro- to nanoscale network assembly consisting of copper ion and epigallocatechin gallate (EGCG) via pi-pi interactions, metal coordination, and oxidative polymerization. The network incorporated rapamycin and immobilized BVLD by the thiol- ene click reaction and provided sustained rapamycin and NO release. Unlike rapamycin-eluting stents, those coated with the EGCG-Cu-rapamycin-BVLD complex favored competitive endothelial cell (EC) growth over that of smooth muscle cells, exhibited long-term antithrombotic efficacy, and attenuated the negative impact of rapamycin on the EC. In vivo stent implantation demonstrated that the coating promoted endothelial regeneration and hindered restenosis. Therefore, the polyphenol-network-mediated surface chemistry can be an effective strategy for the engineering of multifunctional surfaces.
    View publication