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    Altering model cell membranes by means of localized magnetic heating

    Year: 2020

    Journal: Colloid Surf. B-Biointerfaces, Volume 196, DEC

    Authors: Ruiz-Rincon, S; Gonzalez-Orive, A; Grazu, V; Fratila, RM; de la Fuente, JM; Cea, P

    Organizations: European MagicCellGene Project (M-ERA.NET COFUND call 2016 - Ministerio de Ciencia e Innovacion from Spain) [PCIN-2017-127, PCIN-2017-060]; Spanish MINECO [PGC2018-096016-B-I00]; European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [657215]; Ministerio de Economia y CompetitividadSpanish Government; FSE/Agencia Estatal de Investigacion (Ramon y Cajal subprogram) [RYC-2015-17640]; DGA; Fondos FederEuropean Commission [E31_20R, E15_17R]

    Keywords: Model cell membrane; Langmuir-Blodgett films; Magnetic nanoparticles; Alternating magnetic Field

    Isolated iron oxide magnetic nanoparticles (MNPs), 12 nm in diameter, coated with oleic acid molecules as capping agents have been deposited by the Langmuir-Blodgett (LB) method onto a model cell membrane incorporating 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and Cholesterol (Chol) in the 1:1 ratio, which was also fabricated by the LB technique. Atomic Force Microscopy (AFM) experiments showed that the application of an alternating magnetic field results in the embedding of the MNPs through the phospholipidic layer. These experimental results reveal that the heating of individual MNPs may induce a local increase in the fluidity of the film with a large control of the spatial and temporal specificity.
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