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    Are Plant-Based Carbohydrate Nanoparticles Safe for Inhalation? Investigating Their Interactions with the Pulmonary Surfactant Using Langmuir Monolayers

    Year: 2021

    Journal: Langmuir, Volume 37, OCT 26, page 12365–12376

    Authors: Gravel-Tatta, Laurianne; DeWolf, Christine; Badia, Antonella

    Organizations: Natural Sciences and Engineering Research Council of Canada [RGPIN-2019-04883, RGPIN-2019-07043]; National Heart, Lung, and Blood Institute [NIH HL-51177]; Frans Walther's Grand Challenges Explorations (GCE) phase II Award of the Bill & Melinda Gates Foundation [OPP1112090]; Quebec Centre for Advanced Materials of the Fonds de recherche du Quebec.Nature et technologie

    Nanoparticle carriers show promise for drug delivery, including by inhalation, where the first barrier for uptake in the lungs is the monolayer pulmonary surfactant membrane that coats the air/alveoli interface and is critical to breathing. It is imperative to establish the fate of potential nanocarriers and their effects on the biophysical properties of the pulmonary surfactant. To this end, the impact of the nanoparticle surface charge on the lateral organization, thickness, and recompressibility of Langmuir monolayers of model phospholipid-only and phospholipid-protein mixtures was investigated using native and modified forms of nanophytoglycogen, a carbohydrate-based dendritic polymer extracted from corn as monodisperse nanoparticles. We show that the native (quasi-neutral) and anionic nanophytoglycogens have little impact on the phase behavior and film properties. By contrast, cationic nanophytoglycogen alters the film morphology and increases the hysteresis associated with the work of breathing due to its electrostatic interaction with the anionic phospholipids in the model systems. These findings specifically highlight the importance of surface charge as a selection criterion for inhaled nanoformulations.
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