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    Arginine Gemini-Based Surfactants for Antimicrobial and Antibiofilm Applications: Molecular Interactions, Skin-Related Anti-Enzymatic Activity and Cytotoxicity

    Year: 2023

    Journal: Molecules, Volume 28, 2023-01, page 6570

    Authors: Sousa, Francisco Fábio Oliveira de; Pinazo, Aurora; Hafidi, Zakaria; García, María Teresa; Bautista, Elena; Moran, Maria del Carmen; Pérez, Lourdes

    Keywords: cytotoxicity; molecular docking; antimicrobial activity; Langmuir monolayers; biofilm eradication; biofilm inhibition; enzymatic activity; gemini arginine-based surfactants

    The antimicrobial and antibiofilm properties of arginine-based surfactants have been evaluated. These two biological properties depend on both the alkyl chain length and the spacer chain nature. These gemini surfactants exhibit good activity against a wide range of bacteria, including some problematic resistant microorganisms such us methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Moreover, surfactants with a C10 alkyl chain and C3 spacer inhibit the (MRSA) and Pseudomonas aeruginosa biofilm formation at concentrations as low as 8 µg/mL and are able to eradicate established biofilms of these two bacteria at 32 µg/mL. The inhibitory activities of the surfactants over key enzymes enrolled in the skin repairing processes (collagenase, elastase and hyaluronidase) were evaluated. They exhibited moderate anti-collagenase activity while the activity of hyaluronidase was boosted by the presence of these surfactants. These biological properties render these gemini arginine-based surfactants as perfect promising candidates for pharmaceutical and biological properties.
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