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    Bioactive bacterial cellulose–chitosan composite scaffolds for prospective periodontal tissue regeneration

    Year: 2023

    Journal: Journal of Materials Research, Volume 38, 2023-04-01

    Authors: Bokhari, Natasha; Fatima, Tatheer; Nosheen, Sadaf; Iqbal, Farasat; Moeen, Faisal; Sharif, Faiza

    Keywords: Bacterial cellulose; Chitosan; Freeze gelation; Periodontal regeneration

    Periodontal defects due to infections must be treated to reconstruct the shape and characteristics of periodontal tissues including cementum and periodontal ligament. Freeze-dried composite scaffolds were synthesized from bacterial cellulose, chitosan, hydroxyapatite (HA), and pomegranate peel extract (PG extract). The PG is an active wound-healing phytochemical from peels of pomegranate fruit, extracted and characterized through UV, FTIR, and GCMS analysis. These GTR scaffolds were synthesized by freeze gelation using 0.4%, 0.8%, and 1.2%-PG and were freeze dried. Interestingly, the surface morphology revealed 3 distinct microstructures for each composite having porous, and foam-like appearance with interconnected channels. FTIR results suggest the presence of each compound including PG. The XRD results show main peaks of CH, BC, and HA. The extract release from hydrophilic composites was in dose- and time-dependent manner with a microbicidal effect and high biocompatibility and wound-healing ability. Thus, formed scaffolds can be periodontal regenerative materials.
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