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    Biocompatible graft copolymers from bacterial poly(gamma-glutamic acid) and poly(lactic acid)

    Year: 2021

    Journal: Polym. Chem., Volume 12, JUL 14, page 3784–3793

    Authors: Zaccaria, Cristiana L.; Cedrati, Valeria; Nitti, Andrea; Chiesa, Enrica; Martinez de Ilarduya, Antxon; Garcia-Alvarez, Montserrat; Meli, Massimiliano; Colombo, Giorgio; Pasini, Dario

    Organizations: University of Pavia; INSTM (Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali)-Regione Lombardia; Alma Mater Ticinensis Foundation (Excellence in Research, GAMMA-PGA Project); Ministerio de Ciencia e Innovacion of Spain (MCIU/AEI/FEDER, UE) [RTI2018-095041-B-C33]

    We report a novel approach for the modular and convergent construction of biocompatible graft copolymers starting from bacterial poly(gamma-glutamic acid)(gamma-PGA) and incorporating poly(lactic acid) (PLA). This synthesis strategy is controlled at different levels: (a) the choice of a suitable initiator for the ring-opening polymerization of lactide; (b) the chemical elaboration of the polylactic fragments; and (c) their convergent grafting to functionalization of bacterial gamma-PGA propargyl ester using copper(i)-catalyzed alkyne-azide cycloaddition (CuAAC) click chemistry. The graft copolymers are characterized in terms of their thermal and macromolecular properties, their conformational preferences through molecular modelling, and their cytotoxicity.
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