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    Bioinspired by both mussel foot protein and bone sialoprotein: universal adhesive coatings for the promotion of mineralization and osteogenic differentiation

    Year: 2020

    Journal: Polym. Chem., Volume 11, AUG 21, page 4995–5004

    Authors: Long, Xiaoling; Xu, Huilin; Zhang, Dongyue; Li, Jianshu

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51803133, 51973131, 51925304]; State Key Laboratory of Polymer Materials Engineering [sklpme2018-3-10]; Fundamental Research Funds for Central UniversitiesFundamental Research Funds for the Central Universities [YJ201854]

    Generally, the poor osteointegration between bone implant materials and host tissue can lead to severe implant failure, accompanied by a series of postoperative complications. One of the reliable and valid solutions for eliminating these concerns is to improve the biointerface performance of implantsviavarious modification methods. Although some progress has been achieved in recent decades, it still remains a great challenge and requirement to develop a facile and universal method for the implant modification of various materials. In this work, bioinspired by the physiological functions in osteoanagenesis of bone sialoprotein (glutamic acid-rich protein), a series of bi-functional polymers were elaborately designed and synthesized through the reversible addition-fragmentation chain transfer (RAFT) polymerization of methacryloylamido glutamic acid (MGlu) and dopamine methacrylamide (DMA ). Due to the abundant catechol pendants of the polymer chains, these functional polymers are able to form stable coatings on the surfaces of various substratesviaonly an environmentally friendly and mild spin-coating process. Furthermore, the results of mineralization experimentsin vitroclearly indicated that these functional polymeric coatings on titanium plates have the capability to effectively promote mineral deposition. In particular, polymeric coatings composed with a nearly equal monomer composition (1.0/1.2) could induce the formation of calcium phosphate (CaP) with a Ca/P ratio of 1.7/1, which is close to the ratio of calcium to phosphorus in natural hydroxyapatite. Moreover, all of the polymeric coatings facilitated the adhesion, spreading, proliferation, and osteogenic differentiation of MC3T3-E1 cells. These effects were directly affected by the composition of the polymer chains, especially the content of glutamic units.
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