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    Biomimetic microcavity interfaces for a label-free capture of pathogens in the fluid bloodstream by vortical crossflow filtration

    Year: 2021

    Journal: Nanoscale, Volume 13, SEP 28, page 15220–15230

    Authors: Zheng, Liyuan; Zheng, Xiaobo; Yuan, Shanshan; Xu, Weide; Zhang, Changhuan; Zhang, Xingding; Fan, Zhiyuan; Wang, Jilong; Wang, Zheng; Huang, Jinhai; Deng, Junjie

    Organizations: National Nature Science Foundation of China [31971260]; Zhejiang Provincial Natural Science Funds for Distinguished Young Scholar [LR20C100001]; Zhejiang Provincial Natural Science Foundation of China [LY19C100002]; Key Laboratory of Orthopaedics of Zhejiang Province [ZJGK1804Y]; Wenzhou Scientific Research Project [Y20190136]; Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2019004]; Engineering Research Centre of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province [WIBEK181008]

    Bacterial sepsis is a lethal disease triggered by microbial pathogens. The blood pathogen load is a major contributor to both disease severity and mortality in patients with sepsis blood. Therefore, it is crucial to reduce the load of pathogens, in particular the drug-resistant pathogens. In this work, inspired by the crossflow filtration mechanism in suspension-feeding fish, we developed a biomimetic microcavity interface to mimic a porous gill-raker surface as a blood-cleansing dialyzer for sepsis therapy, which can rapidly, safely and efficiently clear bacteria from the fluidic blood. The microcavity interface consists of microcavity arrays, the innerface of which contains nanowire forests. By precisely controlling the pore size of the microcavity and directing the axial travel of the fluid, the bacteria can be isolated from the whole blood without disturbing any blood components or blocking the blood cell transportation. In addition, the three-dimensional nanowire forests assist in the formation of vortices with reduced blood flow velocity and increased resistance to bacterial deposition in situ. Functional modification is not required to recognize the bacteria specifically in our designed dialyzer. Moreover, the microcavity interface clears over 95% bacteria from a fluid blood sample without inducing protein adsorption or complement and platelet activation when contacting the fluid blood. The study supports this biomimetic microcavity interface to be a promising extracorporeal blood-cleansing device in clinical settings.
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