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    Buildup of hyperbranched polymer/alginate multilayers and their influence on protein adsorption and platelet adhesion

    Year: 2017

    Journal: J. Appl. Polym. Sci., Volume 134, MAY

    Authors: Liang, Su; Zhou, Ning; Yu, Shan; Polotakos, N.; Deng, Jun; Moya, Sergio Enrique; Gao, Changyou

    Keywords: biocompatibility; biomaterials; hyperbranched polymers; proteins; surfaces and interfaces

    A hyperbranched poly(methylene bisacrylamide-aminoethyl piperazine) (HPMA) and lactobionic acid modified hyper-branched poly(methylene bisacrylamide-aminoethyl piperazine) (LA-HPMA), namely, galactosylated HPMA, were assembled with alginate through the application of the layer-by-layer technique to fabricate polyelectrolyte multilayer (PEM) films. We monitored the assembly process to reveal the stepwise mass increase with a quartz crystal microbalance with the dissipation technique and by the reversal of the zeta potential. The thickness of PEMs assembled in solutions with different pHs was measured by spectroscopic ellipsom-etry; it showed a general decreasing tendency along with the pH increase. Postincubation in a buffer solution revealed that the multilayers possessed good stability with a thickness decrease from 5 to 15%. The PEMs showed a limited protein adsorption. Serum, bovine serum albumin, and fibrinogen were adsorbed onto the multilayers with a density within hundreds of nanograms per square centimeter to 1 mu g/ cm(2) and showed a relatively smaller adsorption on the multilayers assembled at pH 9. The PEMs assembled with LA-HPMA showed the lowest adhesion and activation of platelets, regardless of the outmost layer. (C) 2017 Wiley Periodicals, Inc.
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