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    Carboxymethyl chitosan grafted trisiloxane surfactant nanoparticles with pH sensitivity for sustained release of pesticide

    Year: 2020

    Journal: Carbohydr. Polym., Volume 243, SEP 1

    Authors: Zhao, Ming; Zhou, Hongjun; Chen, Long; Hao, Li; Chen, Huayao; Zhou, Xinhua

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21576303]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2017A030311003]; Science Technology Program of Guangzhou, China [201903010011]; Innovation Team of Modern Agricultural Industry Technology System of Guangdong Province [2019KJ140]; Innovation Team Project by the Department of Education of Guangdong Province [2018KCXTD015]; College Students Innovation and Entrepreneurship Training Program [2019A07]

    Keywords: Carboxymethyl chitosan; Trisiloxane surfactant; Avermectin; Sustained release; pH sensitivity

    A trisiloxane surfactant (TSS) was grafted onto an intermediate, formed by the reaction of allyl glycidyl ether (AGE) with carboxymethyl chitosan (CMCS), to obtain amphiphilic CMCS-AGE-TSS. Avermectin (AVM) was used as a model pesticide and CMCS-AGE-TSS@AVM nanoparticles were prepared by self-assembly. The structures and morphologies of the nanoparticles were studied by FT-IR and H-1 NMR spectroscopy, XRD, SEM, TGA, DSC, and DLS techniques. The average particle size of CMCS-AGE-TSS@AVM was 210 nm, with encapsulation efficiency of 66 %. With increase in TSS content, the contact angle on the leaf surface decreased from 73.62 degrees for CMCS to 49.32 degrees for CMCS-AGE-TSS. The half-life of AVM encapsulated in the polymer shell increased from 45 min to 83 min. Moreover, sustained release of the drug showed a significant response to pH. Finally, the difference in toxicities between CMCS-AGE-TSS@AVM and pure AVM was not significant.
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