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    Congo Red as a Supramolecular Carrier System for Doxorubicin: An Approach to Understanding the Mechanism of Action

    Year: 2022

    Journal: Int. J. Mol. Sci., Volume 23, AUG

    Authors: Kwiecinska, Klaudia; Stachowicz-Kusnierz, Anna; Korchowiec, Beata; Roman, Maciej; Kwiatek, Wojciech M.; Jagusiak, Anna; Roterman, Irena; Korchowiec, Jacek

    Organizations: InterDokMed project [POWR.03.02.00-00-I013/16]; Polish National Science Centre [2016/21/D/NZ1/02763]; Malopolska Regional Operational Program, Measure 5.1 Krakow Metropolitan Area as an important node of the European research area [MRPO.05.01.00-12-013/15]; project HPC Infrastructure for Grand Challenges of Science and Engineering

    Keywords: doxorubicin; Langmuir films; drug-membrane interactions; Raman spectroscopy; molecular dynamics simulations; drug carrier

    The uptake and distribution of doxorubicin in the MCF7 line of breast-cancer cells were monitored by Raman measurements. It was demonstrated that bioavailability of doxorubicin can be significantly enhanced by applying Congo red. To understand the mechanism of doxorubicin delivery by Congo red supramolecular carriers, additional monolayer measurements and molecular dynamics simulations on model membranes were undertaken. Acting as molecular scissors, Congo red particles cut doxorubicin aggregates and incorporated them into small-sized Congo red clusters. The mixed doxorubicin/Congo red clusters were adsorbed to the hydrophilic part of the model membrane. Such behavior promoted transfer through the membrane.
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