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    Cupric oxide nanoparticles incorporated poly(hydroxybutyrate) nanocomposite for potential biosensing application

    Year: 2022

    Journal: Int. J. Biol. Macromol., Volume 213, JUL 31, page 1018–1028

    Authors: Bakhtiyar, Muhammad Junaid; Raza, Zulfiqar Ali; Aslam, Muhammad; Bajwa, Sadia Zafar; Rehman, Muhammad Shoaib Ur; Rafiq, Samvia

    Organizations: Higher Education Commission, Pakistan [NRPU-9566]

    Keywords: Biosensing; Nanobiocomposite; Polyhydroxybutyrate

    We report the synthesis of a novel electrochemical biosensor comprising of cupric oxide (CuO) nanoparticles (NPs) mediated poly(hydroxybutyrate) (PHB) composite film with polyvinyl alcohol (PVA) as a binder/template support using the solution casting method for the detection of a biomolecule i.e., ascorbic acid (AA). The specimens were characterized for surface, chemical, mechanical, optical, and electrochemical attributes. The results expressed regular mediation of CuO NPs in the PHB/PVA matrix towards nanobiocomposite formation with enhanced crystallinity, inter-molecular interactions, mechanical, and electrochemical attributes, and decreased hydrophilicity and bandgap, thus being useful in potential optoelectronic devices. The synthesized biocomposite film exhibited a tensile strength of 86.24 +/- 4.10 N which might be due to reinforcement/uniform dispersion of the CuO nanofiller in the PHB-based matrix. The PHB/CuO composite, then, deposited on a glassy carbon electrode surface exhibited good electrocatalytic activity towards the AA in the aqueous media even at low analyte concentrations. Such modified electrode surfaces with metal/biopolymer complex could find possible applications in the detection of other bioactive molecules.
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