Contact
    Start Publications De Novo Engineering of Metal-Organic Framework-Printed In Vitro ...
    ←  Publication Finder
    QSense

    De Novo Engineering of Metal-Organic Framework-Printed In Vitro Diagnostic Devices for Specific Capture and Release of Tumor Cells

    Year: 2021

    Journal: Small, Volume 17, NOV

    Authors: Liang, Jieying; Liu, Jian; Lord, Megan S.; Wang, Yu; Liang, Kang

    Organizations: Australia National Health and Medical Research Council (NHMRC) [GNT1163786]; Australian Research Council (ARC) [DP210100422, DP190101008]; Scientia program at UNSW

    Keywords: boronic acid; in vitro diagnostic devices (IVDs); metal-organic frameworks; nanotechnology; tumor cells

    Herein, a paper-based in vitro diagnostic device (IVD) is developed via inkjet printing of de novo engineered, boronic acid-rich metal-organic frameworks (BMOFs). The newly developed BMOFs simultaneously possess crystalline and amorphous structure, mesopore size, large surface area, and retain a high level of boronic acid integration. After printing the BMOFs on the filter paper, the BMOF-printed paper IVD shows a rapid response time (40 min) towards cancer cell capture and its maximum cell capture capacity reaches approximately (4.5 +/- 1.1) x10(4) cells cm(-2). Furthermore, the BMOF-printed IVD shows nine times higher capture ability of cancer cells than non-cancerous cells, suggesting its excellent selectivity. Importantly, the pH-tunable affinity of BMOF to glucose enables its dual-responsive behavior without affecting cell viability. In addition, a desired cell pattern could be achieved by directly drawing BMOFs onto a silicon substrate, highlighting its capacity as a miniaturized device for tumor cell capture and analysis. This simple and label-free nanoplatform enables new opportunities for designing MOF-based smart devices for diverse biomedical applications such as a cost-effective IVD technologies for cancer diagnosis, genotyping, and prognosis.
    View publication