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    Development of Nontoxic Biodegradable Polyurethanes Based on Polyhydroxyalkanoate and L-lysine Diisocyanate with Improved Mechanical Properties as New Elastomers Scaffolds

    Year: 2019

    Journal: Polymers, Volume 11, DEC

    Authors: Wang, Cai; Xie, Jiapeng; Xiao, Xuan; Chen, Shaojun; Wang, Yiping

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51773120, 51802201]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [03012100005]; Natural Science Foundation of GuangdongNational Natural Science Foundation of Guangdong Province [2016A030313050, 2017A030310045]; Science and Technology Project of Shenzhen City [JCYJ20170412105034748]; Top Talent Launch Scientific Research Projects of Shenzhen [827-000133]

    Keywords: L-lysine diisocyanate; biodegradable; polyurethanes; non-toxic; mechanical performance

    A nontoxic and biodegradable polyurethane was prepared, characterized, and evaluated for biomedical applications. Stretchable, biodegradable, and biocompatible polyurethanes (LPH) based on L-lysine diisocyanate (LDI) with poly(ethylene glycol) (PEG) and polyhydroxyalkanoates(PHA) of different molar ratios were synthesized. The chemical and physical characteristics of the LPH films are tunable, enabling the design of mechanically performance, hydrophilic, and biodegradable behavior. The LPH films have a Young's modulus, tensile strength, and elongation at break in the range of 3.07-25.61 MPa, 1.01-9.49 MPa, and 102-998%, respectively. The LPH films demonstrate different responses to a change of temperature from 4 to 37 degrees C, with the swelling ratio for the same sample at equilibrium varying from 184% to 151%. In vitro degradation tests show the same LPH film has completely different degradation morphologies in pH of 3, 7.4, and 11 phosphate buffered solution (PBS). In vitro cell tests show feasibility that some of the LPH films are suitable for culturing rat bone marrow stem cells (rBMSCs), for future soft-tissue regeneration. The results demonstrate the feasibility of the LPH scaffolds for many biomedical applications.
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