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    Disposable Microfluidic Sensor Based on Nanocellulose for Glucose Detection

    Year: 2019

    Journal: Glob. Chall., Volume 3, FEB

    Authors: Uddin, Khan Mohammad Ahsan; Jokinen, Ville; Ahangiri, Farzin; Franssila, Sarni; Rojas, Orlando J.; Tuukkanen, Sampo

    Organizations: Academy of Finland [264743]

    Keywords: biosensors; colorimetry; diagnostics; glucose oxidase; nanofibrils

    Point-of-care devices that are inexpensive, disposable, and environmentally friendly are becoming increasingly predominant in the field of biosensing and biodiagnostics. Here, microfluidics is a suitable option to endow portability and minimal reagent and material consumption. Nanocellulose is introduced to manufacture microfluidic channels and as a storage and immobilization compartment of glucose oxidase. Improved enzymatic activity retention is demonstrated in a simple and disposable point-of-care diagnostic unit that is able to detect glucose from fluid matrices at 0.1 x 10(-3)m concentration and in less than 10 min. It is concluded that the patterning and fluidic technologies that are possible with nanocellulose enable easily scalable multianalyte designs.
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