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    Elaboration and characterization of curcumin-loaded soy soluble polysaccharide (SSPS)-based nanocarriers mediated by antimicrobial peptide nisin

    Year: 2021

    Journal: Food Chem., Volume 336, JAN 30

    Authors: Luo, Lijuan; Wu, Ying; Liu, Chun; Zou, Yuan; Huang, Liang; Liang, Ying; Ren, Jiali; Liu, Yingli; Lin, Qinlu

    Organizations: National Natural Science Foundation of China [31571874]; Hunan Provincial Natural Science Foundation of China [2019JJ40536]; Scientific Research Foundation of Central South University of Forestry and Technology [2017YJ015]; Program for Science & Technology Innovation Platform of Hunan Province [2017TP1021 kc1704007, 2019TP1029]; Project of Chang-Zhu-Tan National Independent Innovation Demonstration Zone [2018XK2007]; Open Project Program of China-Canada Joint Lab of Food Nutrition and Health, Beijing Technology and Business University (BTBU)

    Keywords: Nisin; Curcumin; Soy soluble polysaccharide; Nano-encapsulation; Nanoparticles; Physicochemical properties; Antioxidant activity; Antimicrobial activity

    Curcumin was recently attracted great interest owing to its multiple bioactivities; however, the use of curcumin was hindered by its poor solubility and stability. In this study, curcumin-nisin-soy soluble polysaccharide nanoparticles (Cur-Nisin-SSPS-NPs, size = 118.76 nm) have been successfully elaborated to improve the application of curcumin. The formation of Cur-Nisin-SSPS-NPs was mediated by amphiphilic and positively charged nisin: SSPS encapsulated nisin, which was mainly driven by electrostatic attraction. And nisin-SSPS complex encapsulated curcumin mainly through hydrophobic interactions between nisin and curcumin. The encapsulation efficiency of curcumin (91.66%) in this novel nanocarriers was significantly higher than that in nanoparticles prepared by a single SSPS (31.82%) or nisin (41.69%), most likely because more hydrophobic regions of nisin were exposed after interacting with SSPS through electrostatic interaction. Consequently, this facile and green nanocarriers improved the solubility/dispersibility and stability of curcumin and nisin, as well as endowed SSPS-based nanoparticles with antioxidant and antimicrobial activities.
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