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    Engineering a multifunctional N-halamine-based antibacterial hydrogel using a super-convenient strategy for infected skin defect therapy

    Year: 2020

    Journal: Chem. Eng. J., Volume 379, JAN 1

    Authors: Chen, Wanjun; Zhu, Yingnan; Zhang, Zhe; Gao, Yue; Liu, Wenxin; Borjihan, Qinggele; Qu, Huihui; Zhang, Yana; Zhang, Yanling; Wang, Yan-Jie; Zhang, Lei; Dong, Alideertu

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51663019, 21621004, 2142260]; Qingdao National Laboratory for Marine Science and Technology [QNLM2016ORP0407]; Tianjin Natural Science FoundationNatural Science Foundation of Tianjin [18JCYB-JC29500]

    Keywords: N-Halogenation; Hyaluronic acid; Hydrogel; Multifunctional; Super-convenient strategy; Infected wound therapy

    Endowing hydrogel with antibacterial capability is promising for tissue repair, but most strategies in the synthesis of antibacterial hydrogel is high-cost and low-yield, suffering from many tedious multi-step reaction procedures to obtain antibacterial function. Taking hyaluronic acid-based hydrogel as an example, we herein report a super-convenient and broad-spectrum effective strategy based on a simple N-halogenation reaction allowing a scalable production of N-halamine-based hydrogel capable of bacteria-killing for infected skin defect therapy. This N-halogenation-based strategy in building antibacterial hydrogel is available to most N-H bond-containing hydrogel, and the specific synthesis is regulatable on-demand by tuning N-halogenation conditions. After a biological systematic evaluation, the hydrogel shows good antibacterial function against bacteria, as well as a low toxicity. Meanwhile, in vivo wound healing test reveals that the hydrogel can resist wound bacterial infection, accelerate the healing process, and promote epithelial regeneration. This contribution demonstrates for the first time that benefiting from its integrated advantages of super-convenience, universality, and scalable producibility, the N-halamine-based hydrogel would be very promising in practical biomedical applications.
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