Contact
    Start Publications Engineering immunomodulatory and osteoinductive implant ...
    ←  Publication Finder
    Attension

    Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking

    Year: 2022

    Journal: Nat. Commun., Volume 13, JAN 10

    Authors: Wang, Tao; Bai, Jiaxiang; Lu, Min; Huang, Chenglong; Geng, Dechun; Chen, Gang; Wang, Lei; Qi, Jin; Cui, Wenguo; Deng, Lianfu

    Organizations: National Natural Science Foundation of China [81972134, 82102535]; National Key Research and Development Program of China [2018YFC1106200]; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20171906]; Shanghai Jiao Tong University Medical and Research Program [YG2021ZD06, ZH2018ZDA04]; China Postdoctoral Science Foundation [2019M661560]; GuangCi Professorship Program of Ruijin Hospital Shanghai Jiao Tong University School of Medicine

    Immune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous biomedical interventions, and the synergistic effect is unclear. Here, a dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn2+) and osteoinductive growth factors (e.g., BMP-2 peptide) is designed via mussel adhesion-mediated ion coordination and molecular clicking strategy. Compared to the bare TiO2 group, Zn2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn2+ and BMP-2 peptide can increase M2 macrophages recruitment by up to 124.7% in vivo and upregulate the expression of M2 cytokine IL-10 by 171%. These benefits eventually significantly enhance bone-implant mechanical fixation (203.3 N) and new bone ingrowth (82.1%) compared to the bare TiO2 (98.6 N and 45.1%, respectively). Taken together, the dual-effect coating can be utilized to synergistically modulate the osteoimmune microenvironment at the bone-implant interface, enhancing bone regeneration for successful implantation.
    View publication