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    Flavin-Conjugated Nanobombs: Key Structural Requirements Governing Their Self-Assemblies' Morphologies

    Year: 2021

    Journal: Bioconjugate Chem., Volume 32, MAR 17, page 553–562

    Authors: Ribes, Jonathan; Beztsinna, Nataliia; Bailly, Remy; Castano, Sabine; Rascol, Estelle; Taib-Maamar, Nada; Badarau, Eduard; Bestel, Isabelle

    Organizations: cryo-TEM platform at CBMN; Ligue Contre le Cancer Foundation (Nano-RF/2017); Ligue Contre le Cancer Foundation (Nano-RF/2019)

    In contrast to artificial molecules, natural photosensitizers have the benefit of excellent toxicity profiles and of life-compatible activating energy ranges. Flavins are such photosensitizers that were selected by nature in a plethora of light-triggered biochemical reactions. Flavin-rich nanoparticles could thus emerge as promising tools in photodynamic therapies and in active-targeting drug delivery. Self-assembled flavin-conjugated phospholipids improve the pharmacokinetics of natural flavins and, in the case of controlled morphologies, reduce photobleaching phenomena. The current article presents a proof of concept for the design of riboflavin-rich nanoparticles of tunable morphology from multilamellar patches to vesicular self-assemblies. Coarse-grained simulations of the self-assembling process revealed the key interactions governing the obtained nanomaterials and successfully guided the synthesis of new flavin-conjugates of predictable self-assembly. The obtained flavin-based liposomes had a 65 nm hydrodynamic diameter, were stable, and showed potential photosensitizer activity.
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