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    Fluorinated sodium carboxymethyl cellulose nanoparticles as carrier for improving adhesion and sustaining release of AVM

    Year: 2021

    Journal: J. Macromol. Sci. Part A-Pure Appl. Chem., Volume 58, JAN 8, page 219–231

    Authors: Su, Shaochun; Chen, Long; Hao, Li; Chen, Huayao; Zhou, Xinhua; Zhou, Hongjun

    Keywords: Fluorinated CMC; avermectin; nanoparticles; adhesion; sustained-release

    The loss and overuse of avermectin (AVM) on protecting plants pose a threat to ecosystems. To increase the efficacy of AVM, fluorinated sodium carboxymethyl cellulose (CMC-g-PHFBA) was synthesized by inducing poly 2, 2, 3, 4, 4, 4-hexafluorobutyl methacrylate (HFBA), and AVM was then enveloped in CMC-g-PHFBA (AVM@CMC-g-PHFBA) via hydrophobic interaction. According to the results, the samples exhibited desirable angle contact (min = 58.18 degrees), retention rate (max = 60%, after water washing) and LHC (15.5 mg/cm(2)) on cucumber leaves. AVM@CMC-g-PHFBA also showed good storage stability with obvious Tyndall effect (size <240 nm and charge <-21 mV) for 11 days, with higher anti-UV property. The loaded AVM nanoparticles can release drugs for 95 h, which can be fitted to a zero-order model under different pH conditions for achieving a prolonged pharmacological action. Moreover, the samples have retained insecticidal activity. Collectively, CMC-g-PHFBA nanoparticles are promising delivery systems of AVM with the adhesive and sustained-release property. [GRAPHICS]
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