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    Gemini histidine based surfactants: Characterization; surface properties and biological activity

    Year: 2019

    Journal: J. Mol. Liq., Volume 289, 1-Sep

    Authors: Pinazo, Aurora; Pons, Ramon; Bustelo, Marta; Angeles Manresa, Maria; Moran, Carmen; Raluy, Miriam; Perez, Lourdes

    Organizations: Ministerio de Economia y Competitividad, Spain [CTQ2017-88948-P, CTQ2014-59632-R]

    Keywords: Gemini surfactants; Histidine; Self-assembly; Langmuir monolayers; Antimicrobial activity; Hemolytic activity; DNA binding

    New gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high efficiency. Their biological properties, antimicrobial and hemolytic activities, depended on the alkyl chain length. These surfactants are active against a wide range of bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Moreover, these gemini surfactants have good DNA binding capacity. These new gemini surfactants show a great potential in cosmetic, food and pharmaceutical industries. (C) 2019 Elsevier B.V. All rights reserved.
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