Contact
    Start Publications Graphene oxide-driven interfacial coupling in laser 3D printed ...
    ←  Publication Finder
    Attension

    Graphene oxide-driven interfacial coupling in laser 3D printed PEEK/PVA scaffolds for bone regeneration

    Year: 2020

    Journal: Virtual Phys. Prototyp., Volume 15, APR 2, page 211–226

    Authors: Feng, Pei; Jia, Jiye; Peng, Shuping; Yang, Wenjing; Bin, Shizhen; Shuai, Cijun

    Organizations: Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51935014, 51905553, 81871494, 81871498, 51705540]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ50774, 2018JJ3671, 2019JJ50588]; JiangXi Provincial Natural Science Foundation of China [20192ACB20005]; Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2018); National Postdoctoral Program for Innovative Talents [BX201700291]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M632983]; Project of Hunan Provincial Science and Technology Plan [2017RS3008]; Project of State Key Laboratory of High Performance Complex Manufacturing, Central South University

    Keywords: Graphene oxide; laser 3D printing; bone scaffold; interfacial coupling

    Blending Polyetheretherketone (PEEK) with Polyvinyl alcohol (PVA) is promising to obtain a composite scaffold combining the excellent biomechanical properties of PEEK and the remarkable degradability of PVA. However, the weak interfacial bonding between nonpolar PEEK and polar PVA would result in poor mechanical properties. In this study, owing to its unique amphiphilic properties, graphene oxide (GO) was employed to enhance the interfacial bonding between PEEK and PVA in PEEK/PVA scaffolds that were fabricated by laser 3D printing. On the one hand, the large pi-conjugated structure of GO formed strong pi-pi interactions with the benzene rings in PEEK. On the other hand, the oxygen-containing groups of GO formed strong hydrogen bonds with the hydroxyl groups of PVA. As a result, the interfacial free energy between PEEK and PVA decreased from 37.4 to 29.6 mJ/m(2) according to the harmonic-mean rule, and the PVA phase in PEEK matrix became much fine and uniform, indicating a reinforced interfacial bonding. Correspondingly, the strength and modulus of PEEK/PVA scaffolds increased by 97.16% and 147.06%, respectively, for a GO loading of 1%. Furthermore, the scaffolds exhibited good hydrophilicity and degradability, and promoted cell attachment and proliferation in vitro and osteogenic differentiation and bone regeneration in vivo.
    View publication