Contact
    Start Publications Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic ...
    ←  Publication Finder
    Attension

    Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation

    Year: 2020

    Journal: Int. J. Bioprinting, Volume 6, page 91–104

    Authors: Shuai, Cijun; Li, Yang; Yang, Wenjing; Yu, Li; Yang, Youwen; Peng, Shuping; Feng, Pei

    Organizations: Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51935014, 51905553, 81871494, 81871498, 51705540]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ50774, 2018JJ3671, 2019JJ50588]; JiangXi Provincial Natural Science Foundation of China [20192ACB20005]; Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2018); Open-End Fund for the Valuable and Precision Instruments of Central South University; National Postdoctoral Program for Innovative Talents [BX201700291]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M632983]; Project of Hunan Provincial Science and Technology Plan [2017RS3008]; Project of State Key Laboratory of High-Performance Complex Manufacturing, Central South University; Fundamental Research Funds for the Central Universities of Central South University [2019zzts141, CX20190197]

    Keywords: Poly-l-lactic acid scaffold; GO; Degradation property; Ester bonds hydrolysis

    Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was introduced into the PLLA scaffold prepared by selective laser sintering to accelerate degradation. The reason was that GO with a large number of oxygen-containing functional groups attracted water molecules and transported them into scaffold through the interface microchannels formed between lamellar GO and PLLA matrix. More importantly, hydrogen bonding interaction between the functional groups of GO and the ester bonds of PLLA induced the ester bonds to deflect toward the interfaces, making water molecules attack the ester bonds and thereby breaking the molecular chain of PLLA to accelerate degradation. As a result, some micropores appeared on the surface of the PLLA scaffold, and mass loss was increased from 0.81% to 4.22% after immersing for 4 weeks when 0.9% GO was introduced. Besides, the tensile strength and compressive strength of the scaffolds increased by 24.3% and 137.4%, respectively, due to the reinforced effect of GO. In addition, the scaffold also demonstrated good bioactivity and cytocompatibility.
    View publication