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    Hemocompatibility Multi-in-One Hydrogel Coating with ROS-Triggered Inflammation Suppression and Anti-Infection Properties for Blood-Contacting Device

    Journal: Biomacromolecules

    Authors: Wei, Yuan; Liu, Jingze; Liu, Gongyan; Gao, Shuai; Wu, Dimeng; Yang, Li; Luo, Rifang; Zhang, Fanjun; Wang, Yunbing

    Organizations: National Key Research and Development Program of China [2020YFC1107301]; Sichuan University [20826041F4205]; Sichuan Science and Technology Program [2021YFH0011, 2022YFH0092]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-I2M-5-013]; Project of Science & Technology Department of Sichuan Province, China [2021YFS0086]; 1.3.5 project for disciplines of excellence, West China hospital, Sichuan University [ZYJC21072]

    In traditional blood-contacting medical devices, in-fection and thrombosis are easily formed on the surface of the materials. In addition, inflammation is also a clinical complication that cannot be ignored. More importantly, there is a mutually promoting relationship between the inflammatory response and the infection as well as thrombosis. In this work, we propose a self-adaptive anti-inflammatory coating strategy combined with anti-infection and anticoagulant capacity, which was accomplished based on nano-Ag particles and dexamethasone (Dex)-loaded hydrogel coating. The coating loaded with nano-Ag endows it with good bactericidal performance, including Gram-positive and Gram-negative bacteria. As an anti-inflammatory drug, Dex was grafted onto hydrogel coating by a reactive oxygen species (ROS)-cleavable thioketal (TK) bond and released upon the trigger of an inflammatory environment, blocking further inflammatory cascade, providing self-adaptive anti-inflammatory properties, and avoiding side effects of the drug. It was demonstrated that the coating worked as a precise strategy to resist coagulation, infection, and inflammation, provided a new perspective for designing clinical complication-conformable coatings, and had great application prospects on blood-contacting medical devices.
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