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    Interaction of naringin and naringenin with DPPC monolayer at the air-water interface

    Year: 2020

    Journal: Colloid Surf. A-Physicochem. Eng. Asp., Volume 584, JAN 2

    Authors: Souza, FR; Fornasier, F; Souza, LMP; Penafiel, MP; Nascimento, JB; Malfatti-Gasperini, AA; Pimentel, AS

    Organizations: FAPERJFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) [210.558/2015, E-26/010.001241/2016]; National Council for Scientific and Technological Development (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [465259/2014-6, 302554/2017-3]; Coordination for the Improvement of Higher Education Personnel (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]; National Institute of Science and Technology Complex Fluids (INCT-FCx); Sao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/50983-3]; Centro Nacional de Pesquisa em Energia e Materiais [20170347, 20180220]

    Keywords: Cancer prevention; Antioxidant; Lung inflammation; Fibrosis; Acute lung injury

    The interaction of naringin and naringenin with DPPC monolayer at the air-water interface was investigated by coarse grained molecular dynamics and grazing incidence X-ray off-specular scattering (GIXOS). By molecular dynamics, we found that the DPPC monolayer is not disturbed by the addition of flavonoids at the surface tension of 28 mN m(-1). The flavonoids are located in the region of phospholipid polar heads. The GIXOS experiments show that the addition of flavonoids does not change the film thickness at the surface tension of 28 mN m-1, which is in excellent agreement with molecular dynamics simulation. Our very preliminary study indicates that DPPC may be used as a delivery system for the administration of naringenin and naringin to the lung.
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