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    Interfacial vibrational spectroscopy and Brewster angle microscopy distinguishing the interaction of terpineol in cell membrane models at the air-water interface

    Year: 2019

    Journal: Biophys. Chem., Volume 246, MAR, page 1–7

    Authors: Jaroque, Guilherme Nunez; Sartorelli, Patricia; Caseli, Luciano

    Organizations: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Nacional FAPESP, Brazil [2015/23446-0, 2013/14262-7]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPq, BrazilNational Council for Scientific and Technological Development (CNPq) [400896/2016-8]

    Keywords: gamma-terpineol; Langmuir monolayers; DPPC; DPPE; Air-water interface

    In this paper, gamma-terpineol, a known monoterpene with biological activity, including in lipidic interfaces, was incorporated in Langmuir monolayers of selected phospholipids as a model for cellular membranes. Surface pressure-area isotherms showed that selected amounts of gamma-terpineol expand DPPC and DPPE monolayers and decreased the monolayer elasticity, confirming the lipid/compound interaction. Characterization with vibrational spectroscopy and Brewster angle microscopy pointed that gamma-terpineol adsorbs on the polar heads of the phospholipids, affecting the gauche conformations of the aliphatic chains, and different patterns were observed for DPPC and DPPE monolayers, indicating a characteristic molecular accommodation of gamma-terpineol along the polar head of the phospholipids. Therefore, distinctive interactions with DPPC and DPPE could be observed regarding the incorporation of gamma-terpineol with each lipid, leading to particular molecular arrangements at the air-water interface and pointing the modulation of the interaction according to the chemical composition of the monolayer.
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