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    Langmuir monolayer study of phospholipid DPPC on the titanium dioxide-chitosan-hyaluronic acid subphases

    Year: 2019

    Journal: Adsorpt.-J. Int. Adsorpt. Soc., Volume 25, APR, page 469–476

    Authors: Ladniak, Agata; Jurak, Malgorzata; Wiacek, Agnieszka Ewa

    Organizations: Ministry of Science and Higher Education of PolandMinistry of Science and Higher Education, Poland [BS-M-03-002-18-D-01]

    Country: Lublin, POLAND

    Keywords: DPPC isotherm; Langmuir technique; Chitosan; Titanium dioxide; Hyaluronic acid

    The studies of model biological membranes consisted of phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were carried out by means of the Langmuir monolayer technique using subphases containing chitosan (Ch), titanium (IV) oxide (TiO2), hyaluronic acid (HA) or mixture of them. The aim was to determine the effect of individual components of subphase and their respective combinations on behavior of the DPPC membrane. The systems were tested at room temperature (20 degrees C) and at a natural pH of about 4.8, which was close to the pH of the human skin (4.7-5.6). The surface pressure-area per molecule (-A) isotherms were obtained. Their analysis showed that all substances studied affected the phospholipid membrane which was revealed in the changes of mean molecular area, compression modulus and pressure of the liquid-expanded/liquid-condensed (LE/LC) phase transition. The results were discussed in terms of the nature and strength of mutual interactions. The more profound effect was found at low surface pressures at which the monolayers occurred in more expanded state. However, at the surface pressure corresponding to that of biological membranes, systems had very similar parameters compared to model DPPC isotherm.
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