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    Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis

    Year: 2019

    Journal: Nanomedicine, Volume 14, APR, page 871–887

    Authors: Sarkar, Amrita; Carvalho, Edmund; D'souza, Anisha A.; Banerjee, Rinti

    Organizations: Department of Biotechnology

    Keywords: apoptosis; collagenase-induced osteoarthritis; DPPC liposome; fish oil protein; gold nanoparticles; surface-active phospholipid mimetic

    Aim: To provide multilayered combination therapies encompassing nanoparticles and organic peptides and to assess their efficacy in the treatment of arthritis. Materials & methods: Fish oil protein (FP) was isolated from fish oil glands and tagged with spherical gold nanoparticles (GNPs). Tagged GNPs were encapsulated in DPPC liposomes (FP-GNP-DPPC) and characterized. Results & conclusion: FP increased the hydrophilicity of GNP, while encapsulation of FP-GNP within liposomes increased the hydrophobicity. In vitro release studies of FP-GNP-DPPC exhibited sustained release of FP in simulated synovial fluid. FP-GNP-DPPC injected into intra-articular joints of rats displayed anti-osteoarthritic effects in osteoarthritic rat model. This is the first study to report the anti-osteoarthritic activity of FP and DPPC encapsulated FP-GNP liposomes.
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