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    Liquid crystals-based sensor for the detection of lithocholic acid coupled with competitive host-guest inclusion

    Year: 2019

    Journal: Colloid Surf. B-Biointerfaces, Volume 173, JAN 1, page 178–184

    Authors: Ma, Hui; Kang, Qi; Wang, Tao; Xiao, Jianhong; Yu, Li

    Organizations: Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21373128]; Scientific and Technological Projects of Shandong Province of China [2014GSF117001]

    Keywords: Liquid crystals; Sodium dodecyl sulphate; Lithocholic acid; beta-Cyclodextrin; Host-guest interaction

    A simple, low-cost and label-free strategy for detecting lithocholic acid (LCA) was designed at the liquid crystals (LCs)/aqueous interface via competitive host-guest inclusion. In this method, sodium dodecyl sulfate (SDS) was initially adsorbed on the fluid interface and induced LCs to adopt the homeotropic ordering. Inclusion complexation of SDS and beta-cyclodextrin (beta-CD) disturbed interaction between LCs and SDS and evoked LCs to keep a tilted alignment. When injecting LCA into the mixed solution of SDS and beta-CD, SDS excluded from the cavity of beta-CD by competitive host-guest inclusion and could be re-adsorbed at the LCs/aqueous interface, resulting in the orientational transition of LCs from tilted to homeotropic state. Correspondingly, a bright-to-dark optical response was observed under polarized optical microscope (POM). The as-prepared LCs-based sensor could detect LCA as low as about 2 mu M in aqueous solution. Moreover, the practicability of the approach was validated by monitoring the known amount of LCA in human urine. This work offers an appealing approach for the detection of LCA which has a great potentiality in clinical diagnosis.
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