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    Liquid Oil Marbles: Increasing the Bioavailability of Poorly Water-Soluble Drugs

    Year: 2019

    Journal: J. Pharm. Sci., Volume 108, JUN, page 2136–2142

    Authors: Janska, Petra; Rychecky, Ondrej; Zadrazil, Ales; Stepanek, Frantisek; Cejkova, Jitka

    Organizations: Czech Science FoundationGrant Agency of the Czech Republic [17-21696Y]; Specific University Research (MSMT)Ministry of Education, Youth & Sports - Czech Republic [21-SVV/2018]

    Keywords: liquid oil marbles; enhanced release; dissolution

    Many new therapeutic candidates and active pharmaceutical ingredients (APIs) are poorly soluble in an aqueous environment, resulting in their reduced bioavailability. A promising way of enhancing the release of an API and, thus, its bioavailability seems to be the use of liquid oil marbles (LOMs). An LOM system behaves as a solid form but consists of an oil droplet in which an already dissolved API is encapsulated by a powder. This study aims to optimize the oil/powder combination for the development of such systems. LOMs were successfully prepared for 15 oil/powder combinations, and the following properties were investigated: particle mass fraction, dissolution time, and mechanical stability. Furthermore, the release of API from both LOMs and LOMs encapsulated into gelatine capsules was studied. (c) 2019 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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