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    Mannose-anchored quaternized chitosan/thiolated carboxymethyl chitosan composite NPs as mucoadhesive carrier for drug delivery

    Year: 2022

    Journal: Carbohydr. Polym., Volume 283, MAY 1

    Authors: Jin, Zheng; Hu, Gaowei; Zhao, Kai

    Organizations: Pioneer and Leading Goose R&D Program of Zhejiang [2022C02031]; National Natural Science Foundation of China [32170844]; Young Eagle Plan for Cultivation Special Project of Scientific and Technological Enterprise in Harbin [2020CYJBCG0306]

    Keywords: Mannose-conjugated chitosan; Thiolated chitosan; Nanoparticles; Drug delivery carrier; Mucosal adhesion; Mucosal administration

    There are various challenges for the mucosal delivery of drug, which is largely attributed to the absence of effective drug carriers that can make delivery to mucosal sites. In the present study, we aimed to synthesize bifunctional mucoadhesive nanoparticles (NPs) that could be used for mucosal delivery. N-2-Hydroxypropyl trimethyl ammonium chloride chitosan (M-N-2-HACC) was modified with D-mannose, and N-acetyl-L-cysteine (NAC) was immobilized on the carboxymethyl chitosan (N-CMCS). The electrostatic interaction between the two substances was used to produce mannose-modified thiolated chitosan NPs (M-N-2-HACC/N-CMCS NPs). The NPs showed a particle size of 196.72 +/- 0.45 nm and zeta potential of 17.12 +/- 0.50 mV. Moreover, it demonstrated high hydrophilicity, enduring drug release, stability, safety, and mucosal adhesion, which contributed to the effectiveness of mucosal administration. Additionally, the NPs could be instantly absorbed by macrophages. Collectively, these results suggested that M-N-2-HACC/N-CMCS NPs could be used as a promising candidate for mucosal delivery.
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