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    Micellar and spectroscopic studies of amphiphilic drug with nonionic surfactant in the presence of ionic liquids

    Year: 2020

    Journal: J. Mol. Liq., Volume 315, OCT 1

    Authors: Azum, Naved; Rub, Malik Abdul; Azim, Yasser; Asiri, Abdullah M.

    Organizations: Saudi Arabia Basic Industries Corporation (SABIC); Deanship of Scientific Research (DSR) at King Abdulaziz University [S:88-130-1440]; DSR

    Keywords: Imipramine hydrochloride; TX-45; Ionic liquids; Mixed micelle; UV-visible spectroscopy

    In this work, we studied the association and spectroscopic behaviour of amphiphilic drug, imipramine hydrochloride (IMP), and nonionic surfactant (TX-45), in the absence and presence of ionic liquid, 1-hexyl-3-methylimidazolium chloride (IL). IMP shows amphiphilic behaviour due to the presence of rigid tricyclic: hydrophobic moiety in the body. Surface tension and absorbance measurements have been performed to study the nature of interactions between IMP and TX-45 mixtures in the nonattendance and attendance of IL. The diverse physical theories of mixed micellization (Clint, Rubingh, Motomura, and Maeda) were utilized to calculate the composition and interaction parameters. The Gibbs adsorption isotherm was adopted to compute the various surface parameters. The interaction between the two amphiphiles also evaluated via UV-visible spectroscopy. (C) 2020 Elsevier B.V. All rights reserved.
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