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    Microscale topographic surfaces modulate three-dimensional migration of human spermatozoa

    Year: 2020

    Journal: Colloid Surf. B-Biointerfaces, Volume 193, SEP

    Authors: Huang, Gui; Li, Sun; Jin, Xueqing; Qi, Meng; Gong, Xiangjun; Zhang, Guangzhao

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21574046, 21973032]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Fund of the Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province, Guangzhou, China (South China University of Technology) [2019B030301003]

    Keywords: Three-dimensional motion; Surface topography; Human spermatozoa; Digital holographic microscopy

    Sperm migration in the female reproductive tract is vital for reproduction. Surface topography is expected to be a vital determinant on this process. Using digital holographic microscopy (DHM), we investigated three-dimensional (3D) motion dynamics of human spermatozoa near a flat glass surface and microscale topographic surfaces with tunable roughness fabricated by a monolayer of closely packed silica colloidal particles. Generally, the rougher surfaces show negative impacts on the sperm migration through the hydrodynamic interactions modulated by surface topography, reflected as oscillating trajectories with wider swimming orientation distribution, reduced 3D velocity and less helical/hyperactivated/hyerhelical motions. Nevertheless, slight difference is observed for the sperm motion near the flat glass surface and the surface with a feature dimension similar to the sperm tail. Our study provides new insights in understanding and manipulating sperm motions.
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