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    Mixed Silane-based Self-assembled Monolayers Deposited on Fluorine Doped Tin Oxide as Model System for Development of Biosensors for Toxin Detection

    Year: 2021

    Journal: Electroanalysis, Volume 33, MAY, page 1315–1324

    Authors: Gabriunaite, Inga; Valiuniene, Ausra; Sabirovas, Tomas; Valincius, Gintaras

    Organizations: European Regional Development Fund under Promotion of Centers of Excellence and Innovation and Technology Transfer Centers program [01.2.2-CPVA-K-703, 01.2.2-CPVA-K-703-03-0010]

    Keywords: biosensors; phospholipid bilayers; monolayers; metal oxide electrodes; electrochemical impedance spectroscopy

    In this work mixed hybrid phospholipid bilayers (mhBLM) were deposited on fluorine doped tin oxide (FTO) films. Two component silane-based self-assembled monolayers (SAMs) formed on FTO surface trigger vesicle fusion and formation of mhBLMs which are stable, can be easily regenerated, and therefore, used for multiple experiments. We found that certain chemical and physical conditions under which mixed SAMs are fabricated translate into functional properties of mhBLMs. In all cases we observed interaction of melittin with mhBLMs demonstrating biological relevance of these biomimetic surface constructs and their possible application in biosensors for toxin detection.
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