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    nMgO-incorporated PLLA bone scaffolds: Enhanced crystallinity and neutralized acidic products

    Year: 2019

    Journal: Mater. Des., Volume 174, JUL 15

    Authors: Shuai, Cijun; Zan, Jun; Qi, Fangwei; Wang, Guoyong; Liu, Zheng; Yang, Youwen; Peng, Shuping

    Organizations: Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871494, 51575537, 81871498, 81572577, 51705540]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2016JJ1027, 2018JJ3671]; Guangdong Province Higher Vocational Colleges AMP; Schools Pearl River Scholar Funded Scheme (2018); Open-End Fund for the Valuable and Precision Instruments of Central South University

    Keywords: PLLA; Bone scaffolds; Mechanical properties; Degradation behavior; Biocompability

    Poly-l-lactic acid (PLEA) is a promising bone repair material because of its good biocompatibility and natural de-gradability. Nevertheless, the poor mechanical properties and local inflammatory response limits its further application in bone repair. In this research, nano magnesium oxide (nMgO) was incorporated into Pills scaffold manufactured by selective laser sintering technique. Results shown that nMgO with good affinity to PLLA could act as nucleating agent during crystallization process and effectively enhance the crystallinity of PLLA, which was proved by the isothermal behavior and non-isothermal behavior analysis. The evolution of crystallization was also achieved by polarized optical microscopy. Mechanical tests confirmed that the tensile strength, young modulus and Vickers hardness of PLLA/3nMgO was enhanced by 38%, 24% and 11%, respectively, as compared with PLLA. On the other hand, the incorporated nMgO neutralized the acid degradation by-products of PLLA, forming a weak alkaline environment which might contribute to avoiding sever local inflammation after implantation. Moreover, in vitro cell culture revealed an improved biocompatibility of PLLA/nMgO scaffolds. All these positive results suggested that PLLA/3nMgO scaffold was a potential material for bone repair application. (C) 2019 The Authors. Published by Elsevier Ltd.
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