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    Nonglutaraldehyde crosslinked bioprosthetic heart valves based on 2-iso-cyanatoethyl methacrylate crosslinked porcine pericardium with improved properties of stability, cytocompatibility and anti-calcification

    Year: 2022

    Journal: Compos. Pt. B-Eng., Volume 230, FEB 1

    Authors: Zheng, Cheng; Ding, Kailei; Huang, Xueyu; Li, Meiling; Wu, Bingang; Lei, Yang; Wang, Yunbing

    Organizations: National Natural Science Foundation of China [32071357, 52003180]; National Key Research and Development Programs, China [2020YFC1107802]; Applied Basic Research of Science and Technology Projects of Sichuan Province [2018JY0538]; 111 Project of Introducing Talents of Discipline to Universities, China [B16033]; Sichuan Science and Technology Program [2021YFH0011]

    Keywords: Bioprosthetic heart valves; Stability; Cytocompatibility; Anti-calcification; Hydrodynamic performance and durability

    Valvular heart diseases (VHD) have a high incidence in the elderly, and the morbidity and fatality rate of VHD increase gradually. To save the lives of patients at the end stage of VHD, valve replacement is the most effective treatment. Owning to the good hydrodynamic performance and application of transcatheter aortic valve replacement (TAVR), bioprosthetic heart valves (BHVs) fabricated from glutaraldehyde crosslinked porcine or bovine pericardium have become a popular choice for patients. However, BHVs fail within 10-15 years of implantation due to the structural degradation and calcification which are greatly attributed to glutaraldehyde crosslinking. In this work, 2-isocyanatoethyl methacrylate (ICM) was used as crosslinking agent for the first time to stabilize porcine pericardium by radical polymerization crosslinking. The ICM-crosslinked pericardium (PICM10-PP) was demonstrated to exhibit better cytocompatibility, mechanical property, and milder immune responses compared with glutaraldehyde crosslinked porcine pericardium (GA-PP). In addition, the PICM10-PP was less calcific than GA-PP after 30 and 90 days of subcutaneous implantation. Following the guidance of ISO5840-3, the hydrodynamic performance and durability of PICM10-PP were evaluated and demonstrated to conform the requirements for BHVs. These results indicate that ICM is a potential alternative of glutaraldehyde in crosslinking BHVs.
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