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    Novel Nanostructured Scaffolds of Poly(butylene trans-1,4-cyclohexanedicarboxylate)-Based Copolymers with Tailored Hydrophilicity and Stiffness: Implication for Tissue Engineering Modeling

    Year: 2023

    Journal: Nanomaterials, Volume 13, 2023-01, page 2330

    Authors: Guidotti, Giulia; Soccio, Michelina; Argentati, Chiara; Luzi, Francesca; Aluigi, Annalisa; Torre, Luigi; Armentano, Ilaria; Emiliani, Carla; Morena, Francesco; Martino, Sabata; Lotti, Nadia

    Keywords: hydrophilicity; mechanical properties; biocompatibility; 4-cyclohexanedicarboxylate); adult human multipotent mesenchymal/stromal cells; electrospun scaffolds; ether linkages; flexibility; poly(butylene trans-1; stem cells culture

    Here, we present novel biocompatible poly(butylene trans-1,4-cyclohexanedicarboxylate) (PBCE)-based random copolymer nanostructured scaffolds with tailored stiffness and hydrophilicity. The introduction of a butylene diglycolate (BDG) co-unit, containing ether oxygen atoms, along the PBCE chain remarkably improved the hydrophilicity and chain flexibility. The copolymer containing 50 mol% BDG co-units (BDG50) and the parent homopolymer (PBCE) were synthesized and processed as electrospun scaffolds and compression-molded films, added for the sake of comparison. We performed thermal, wettability, and stress–strain measures on the PBCE-derived scaffolds and films. We also conducted biocompatibility studies by evaluating the adhesion and proliferation of multipotent mesenchymal/stromal cells (hBM-MSCs) on each polymeric film and scaffold. We demonstrated that solid-state properties can be tailored by altering sample morphology besides chemical structure. Thus, scaffolds were characterized by a higher hydrophobicity and a lower elastic modulus than the corresponding films. The three-dimensional nanostructure conferred a higher adsorption protein capability to the scaffolds compared to their film counterparts. Finally, the PBCE and BDG50 scaffolds were suitable for the long-term culture of hBM-MSCs. Collectively, the PBCE homopolymer and copolymer are good candidates for tissue engineering applications.
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