Contact
    Start Publications Peptidoglycans modulating the interaction of a bactericide ...
    ←  Publication Finder
    KSV NIMA

    Peptidoglycans modulating the interaction of a bactericide compound with lipids at the air-water interface

    Year: 2021

    Journal: Chem. Phys. Lipids, Volume 237, JUL

    Authors: Jaroque, Guilherme Nunez; Sartorelli, Patricia; Caseli, Luciano

    Organizations: FAPESP [2019/03239-0, 2018/22214-6]; CNPq [301354/2019-7]

    Keywords: Peptidoglycans; Terpineol; Langmuir monolayers; Air-water interface

    A known monoterpene, named.-terpineol, was incorporated in mixed Langmuir monolayers composed of dipalmitoyl-phosphoethanolamine (DPPE) and peptidoglycans as a model of microbial membranes. Surface pressure and surface potential isotherms, dynamical surface rheology, Brewster angle microscopy (BAM), and infrared spectroscopy were employed to characterize the compound-membrane interactions. The compound expanded the monolayers denoting repulsive interactions. At 30 mN/m, the monolayer presented lower viscoelastic and in-plane elasticity parameters and an increased all-trans/gauche conformers ratio for the alkyl chains, confirming molecular order. The morphology of the monolayer was analyzed by BAM, which revealed a heterogeneous distribution of gamma-terpineol along the mixed monolayer, which tends to segregate. In conclusion, the compound changes the thermodynamic, electric, rheological, morphological, and structural properties of the peptidoglycan-DPPE monolayer, which may be essential to understand, at the molecular level, the action of bioactives in selected membrane models.
    View publication