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    Performance of polyvinyl pyrrolidone-isatis root antibacterial wound dressings produced in situ by handheld electrospinner

    Year: 2020

    Journal: Colloid Surf. B-Biointerfaces, Volume 188, APR

    Authors: Dong, Wen-Hao; Liu, Jia-Xu; Mou, Xiao-Ju; Liu, Guo-Sai; Huang, Xiao-Wei; Yan, Xu; Ning, Xin; Russell, Stephen J.; Long, Yun-Ze

    Organizations: National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51703102, 51973100, 51673103]; Innovation and Entrepreneurship Training Program for College Students of Qingdao University [X2018110650078]

    Keywords: In situ electrospinning; PVP fibers; Isatis root; Wound dressing

    Antibacterial dressings are an increasingly important tool for the prevention and management of wound infections, particularly in light of concerns surrounding conventional drug-resistant antibiotics. Handheld electrospinning devices provide opportunities for the rapid application of antibacterial dressing materials to wounds, but spinning formulations need to be compatible with live biological surfaces. We report the development of a new antibacterial formulation compatible with handheld electrospinning, and its manufacture directly on a wound site. Nanofibrous dressing mats were produced from polyvinyl pyrrolidone (PVP) containing isatis root (Indigowoad root or Ban-Lan-Gen), a traditional Chinese medicine, commonly used for the treatment of infectious disease. The resulting wound dressing mats of PVP/isatis root exhibited well-defined fibrous structures and excellent surface wetting, and permeability characteristics. The presence of isatis root conferred antibacterial activity against gram negative and gram positive strains. Moreover, in a Kunming mouse skin injury model, direct electrospinning of PVP/isatis root formulations on to wound sites produced near complete wound closure after 11 days and epidermal repair in histological studies.
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