Contact
    Start Publications Phosphonic Acid Coupling Agent Modification of HAP ...
    ←  Publication Finder
    Attension

    Phosphonic Acid Coupling Agent Modification of HAP Nanoparticles: Interfacial Effects in PLLA/HAP Bone Scaffold

    Year: 2020

    Journal: Polymers, Volume 12, JAN

    Authors: Shuai, Cijun; Yu, Li; Yang, Wenjing; Peng, Shuping; Zhong, Yancheng; Feng, Pei

    Organizations: Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51935014, 51905553, 81871494, 81871498, 51705540]

    Keywords: interfacial bonding; coupling agent; HAP; scaffold

    In order to improve the interfacial bonding between hydroxyapatite (HAP) and poly-l-lactic acid (PLLA), 2-Carboxyethylphosphonic acid (CEPA), a phosphonic acid coupling agent, was introduced to modify HAP nanoparticles. After this. the PLLA scaffold containing CEPA-modified HAP (C-HAP) was fabricated by selective laser sintering (frittage). The specific mechanism of interfacial bonding was that the PO32- of CEPA formed an electrovalent bond with the Ca2+ of HAP on one hand, and on the other hand, the -COOH of CEPA formed an ester bond with the -OH of PLLA via an esterification reaction. The results showed that C-HAP was homogeneously dispersed in the PLLA matrix and that it exhibited interconnected morphology pulled out from the PLLA matrix due to the enhanced interfacial bonding. As a result, the tensile strength and modulus of the scaffold with 20% C-HAP increased by 1.40 and 2.79 times compared to that of the scaffold with HAP, respectively. In addition, the scaffold could attract Ca2+ in simulated body fluid (SBF) solution by the phosphonic acid group to induce apatite layer formation and also release Ca2+ and PO43- by degradation to facilitate cell attachment, growth and proliferation.
    View publication