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    Polybutylene-adipate-terephthalate and niobium-containing bioactive glasses composites: Development of barrier membranes with adjusted properties for guided bone regeneration

    Year: 2021

    Journal: Mater. Sci. Eng. C-Mater. Biol. Appl., Volume 125, JUN

    Authors: Balbinot, Gabriela de Souza; Bahlis, Eduardo Antunes da Cunha; Visioli, Fernanda; Leitune, Vicente Castelo Branco; Soares, Rosane Michele Duarte; Collares, Fabricio Mezzomo

    Organizations: CAPES Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil [001]; CNPq Conselho Nacional de Desenvolvimento Cientifico e Tecnologico

    Keywords: Regenerative medicine; Guided tissue regeneration; Alveolar ridge augmentation; Biopolymer; Niobium

    This study aimed to develop bioactive guided bone regeneration (GBR) membranes by manufacturing PBAT/ BAGNb composites as casting films. Composites were produced by melt-extrusion, and BAGNb was added at 10 wt%, 20 wt%, and 30 wt% concentration. Pure PBAT membranes were used as a control (0wt%BAGNb). FTIR and thermogravimetric analysis characterized the composites. Barrier membranes were produced by solvent casting, and their mechanical and surface properties were assessed by tensile strength test and contact angle analysis, respectively. The ion release and cell behavior were evaluated by pH, cell proliferation, and mineralization. Composites were successfully produced, and the chemical structure showed no interference of BAGNb in the PBAT structure. The addition of BAGNb increased the stiffness of the membranes and reduced the contact angle, increasing the roughness in one side of the membrane. Sustained pH increment was observed for BAGNbcontaining membranes with increased proliferation and mineralization as the concentration of BAGNb increases. The incorporation of up to 30 wt% of BAGNb into PBAT barrier membranes was able to maintain adequate chemical-mechanical properties leading to the production of materials with tailored surface properties and bioactivity. Finally, this biomaterial class showed outstanding potential and may contribute to bone formation in GBR procedures.
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