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    Reversible 2D networks of oligo(epsilon-caprolactone) at the air-water interface

    Year: 2019

    Journal: Biomed. Mater., Volume 14, MAY

    Authors: Saretia, Shivam; Machatschek, Rainhard; Schulz, Burkhard; Lendlein, Andreas

    Organizations: Helmholtz Graduate School for Macromolecular Bioscience; Helmholtz AssociationHelmholtz Association

    Keywords: poly(epsilon-caprolactone); langmuir monolayer; two dimensional network; crystallization; cross-linking

    Hydroxyl terminated oligo(epsilon-caprolactone) (OCL) monolayers were reversibly cross-linked forming two dimensional networks (2D) at the air-water interface. The equilibrium reaction with glyoxal as the cross-linker is pH-sensitive. Pronounced contraction in the area of the prepared 2DOCL films in dependence of surface pressure and time revealed the process of the reaction. Cross-linking inhibited crystallization and retarded enzymatic degradation of the OCLfilm. Altering the subphase pH led to a cleavage of the covalent acetal cross-links. The reversibility of the covalent acetal cross-links was proved by observing an identical isotherm as non-cross-linked sample. Besides as model systems, these customizable reversible OCL2D networks are intended for use as pHresponsive drug delivery systems or functionalized cell culture substrates.
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