Contact
    Start Publications Roles of surfactant and polymer in drug release from ...
    ←  Publication Finder
    Attension

    Roles of surfactant and polymer in drug release from spray-dried hybrid nanocrystal-amorphous solid dispersions (HyNASDs)

    Year: 2020

    Journal: Powder Technol., Volume 361, FEB 1, page 663–678

    Authors: Rahman, Mahbubur; Ahmad, Stephanie; Tarabokija, James; Bilgili, Ecevit

    Keywords: Wet stirred media milling; Spray drying; Drug nanoparticles; Nanocomposites; Supersaturation; Dissolution

    We prepared hybrid nanocrystal-amorphous solid dispersions (HyNASDs) to enhance the dissolution of a poorly soluble drug, griseofulvin (GF), and elucidated the roles of a surfactant, sodium dodecyl sulfate (SDS), and two polymers, HPC and Soluplus. Wet-milled suspensions containing 1:1 to 1:5 GF:polymer mass ratios, with and without SDS, were spray-dried. HyNASD formation was confirmed via DSC, XRPD, and Raman spectroscopy. In dissolution tests, due to its sub-ambient glass transition temperature, poor miscibility with GF, its inability to inhibit GF recrystallization, HPC provided HyNASDs with low supersaturation capability (<= 50%) even at the highest loading (1:5) with/without SDS. Contrarily, owing to its stronger intermolecular interactions-miscibility with GF, and its kinetic solubilization-inhibition of GF recrystallization observed in desupersaturation tests, Soluplus, with SDS, in HyNASDs achieved remarkably high supersaturation (>250%). SDS provided enhanced wettability, allowing for fast supersaturation from Soluplus-based HyNASDs (similar to 300% within 20 min), while higher Soluplus loading led to higher supersaturation. (C) 2019 Elsevier B.V. All rights reserved.
    View publication