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    Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity

    Year: 2020

    Journal: J. Mater. Sci. Technol., Volume 48, JUL 1, page 130–139

    Authors: Liu, Hui; Liu, Rui; Ullah, Ihsan; Zhang, Shuyuan; Sun, Ziqing; Ren, Ling; Yang, Ke

    Organizations: National Key Research and Development Program of China [2018YFC1106601, 2016YFC1100601]; LiaoNing Revitalization Talents Program [XLYC1807069]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [51631009, 31870954]; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences [174321KYSB2018000]

    Keywords: Titanium; Copper; Roughness surface; Osteogenesis; Antibacterial

    Implant-related infection and early bone integration are the main risk factors of implants for long-term service, to overcome these difficulties, SLA-TiCu surface was prepared by sandblasting and large-grits etching (SLA) treatment on a novel antibacterial titanium-copper alloy (TiCu), which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants. Effects of SLA-TiCu surface on the adhesion, proliferation, apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen (Staphylococcus aureus) were studied. Compared to the following surfaces: sandblasting and large-grits etched pure titanium (SLA-Ti), mechanically ground pure titanium and TiCu alloy (M-Ti and M-TiCu), these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions (alkaline phosphates (ALP), collagen type I (COL I), Runt-related transcription factor 2 (RUN x 2), and osteopontin (OPN)). Moreover, SLA-TiCu surface could maintain a sustainable release of Cu2+ ions and effectively inhibited the viability of bacteria. This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity, making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
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